Clinicopathological Correlation of Non-Neoplastic Dermatoses: A Prospective Tertiary Care Study
Keywords:
Non-neoplastic skin lesions; Histopathology; Dermatopathology; Hansen’s disease; Clinicopathological correlation; Skin biopsyAbstract
Background: Non-neoplastic skin lesions represent a major proportion of dermatological disorders encountered in routine clinical practice. Due to overlapping clinical presentations, accurate diagnosis based solely on clinical examination is often challenging. Histopathological examination remains the gold standard for definitive diagnosis and plays a pivotal role in guiding appropriate clinical management.
Objectives: To study the histomorphological spectrum of non-neoplastic skin lesions and to evaluate the clinicopathological correlation in patients attending a tertiary care hospital.
Materials and Methods: This prospective observational study included 56 skin biopsy specimens from clinically suspected non-neoplastic skin lesions received in the Department of Pathology, Hind Institute of Medical Sciences, Sitapur. Biopsy specimens were fixed in 10% buffered formalin, routinely processed, and stained with hematoxylin and eosin. Special stains such as Ziehl–Neelsen, Fite–Faraco, Periodic Acid–Schiff, and Masson’s Trichrome were used where indicated. Clinical findings were correlated with histopathological diagnoses. Data were analysed using descriptive statistics.
Results: Of the 56 cases studied, 34 (60%) were males, and 22 (40%) were females, showing a male predominance. The majority of patients belonged to the 21–40-year age group. Hansen’s disease was the most common histopathological diagnosis (34.3%), followed by bullous disorders (17.1%). Histopathological examination confirmed the clinical diagnosis in most cases and identified additional unsuspected lesions in a few cases.
Conclusion: Non-neoplastic skin lesions predominantly affect young and middle-aged adults, with a male preponderance. Histopathological evaluation remains indispensable for accurate diagnosis, classification, and effective management of these lesions. Early biopsy and strong clinicopathological correlation significantly enhance diagnostic accuracy and patient care.
DOI: 10.8612/40.4.2025.3
