Antibiotic Resistance and Rational Drug Use: Clinical Challenges, Stewardship, and Future Directions

Abstract

Antibiotic resistance has become a global clinical and public health challenge, fueled by irrational prescribing, overuse, and patient non-adherence. It results in increased morbidity, mortality, and economic burden. This review examines the clinical impact of antibiotic resistance, strategies for rational drug use, antimicrobial stewardship programs, and emerging interventions for resistance mitigation. Emphasis is placed on optimizing clinical prescribing practices and integrating diagnostics for evidence-based therapy.

DOI: 10.8612/36.2.2021.2